The fantasy dragons-and-swords saga, which already has 38 Emmys under its belt, is not expected back on screens until next year.
The drama missed the awards in 2017 because of its production schedule but this year’s nominations include nods for cast members Lena Headey, Nikolaj Coster-Waldau and Peter Dinklage.
HBO’s Game of Thrones is closely followed by dystopian sci-fi series The Handmaid’s Tale, which gained 20 nominations and won top drama last year.
Netflix is the most nominated network, with 112 – breaking a 17-year streak at the top for HBO.
Its nominated shows include sci-fi drama Stranger Things, fictionalised royal biopic The Crown, comedy GLOW and western Godless.
The top comedy nominee is Donald Glover‘s Atlanta, with 16.
The revival of Roseanne, cancelled following a racist tweet posted by comedian Roseanne Barr, drew only one major nomination – supporting actress for Laurie Metcalf.
Comedy show Saturday Night Live, which has been enjoying high ratings due to its focus on the Trump administration, was rewarded with 21 nominations.
The 70th Emmys ceremony will take place in September and be hosted by comedians Colin Jost and Michael Che.