An injury-blighted decade later, Woods is back among the favourites for the 2018 edition at Shinnecock Hills, but there have been several near misses since in his search for a 15th major.
We take a look at the six here…
2009 PGA Championship, Hazeltine
Woods was either in the lead or tied for the lead heading into the final day of every single one of his 14 major wins, and this was the only time he’s led after 54 holes and not won.
Woods was two shots clear heading into the Sunday at Hazeltine, but he laboured around the final 18 as Yang Yong-eun stormed to victory. Woods made five bogeys and just two birdies in a round of 75, while Yang’s 70, including an eagle on the 14th, saw him storm to victory.
Woods has not finished in the top 10 at the PGA Championship since and has failed to even made the cut since 2013.
Woods had won the Masters on four previous occasions and recorded six other top-10 finishes, but he’d never shot a first round under 70 until 2010, where an opening 68 saw him just two shots off the lead on the opening day.
He failed to really capitalise on that strong start, however, as he followed it up with two rounds of 70 to leave himself four shots off leader Lee Westwood heading into the final round.
And three bogeys in the opening five holes on the Sunday effectively ended his chances, even though two eagles later on saw him finish 11 under for the tournament, five off winner Phil Mickelson.
2010 US Open, Pebble Beach
Woods struggled through the two opening rounds at Pebble Beach as he carded a 74 and 72 to head into the weekend four over par.
A storming 66, however, put him right back into contention as he started the fourth day five shots off leader Dustin Johnson.
Johnson would make an 82 on the Sunday to slip right out of contention, but Woods couldn’t capitalise as he could only make a 75 himself to finish three shots behind winner Graeme McDowell.
Woods couldn’t get in the 60s in his opening round for a second year in a row at Augusta, but a strong second day showing of 66 left him seven under, three off leader Rory McIlroy.
Woods couldn’t maintain that form on the Saturday though as his two over 74 left him seven off the Northern Irishman. McIlroy, however, imploded on the final day and allowed the chasing pack back in.
Woods shot 31 on the front nine to take a tie for the lead, but a bogey on the 12th saw him slip away and he couldn’t keep pace with those around him as he eventually finished four shots off winner Charl Schwartzel in a tie for fourth.
2012 Open Championship, Royal Lytham & St Annes
Woods hadn’t really challenged at the Open since his last success there in 2006, but two opening rounds of 67 would immediately put him into contention at Royal Lytham & St Annes.
He started day three four shots off the lead but could only manage par to slip five off Adam Scott heading into the final day.
Scott would go on to struggle on the Sunday which allowed Ernie Els to sneak in from a shot behind Woods to claim the Claret Jug on seven under. Woods finished three over on the final day, tied for third and four shots behind Els. Yet again another poor final round, including a double bogey on the sixth, had let him down.
Woods finished tied for 40th at the 2012 Masters, his lowest Augusta finish since 2012, but bounced back strongly 12 months later.
A 70, 73 and 70 left him three under heading into the final day, four shots off leader Angel Cabrera, but a poor front nine on the Sunday meant Woods had a mountain to climb.
He responded well on the back nine with three birdies but a five-under finish meant he was four shots off Adam Scott and Angel Cabrera in a tie for fourth, with the Australian going on to win the play-off.