The list identifies and ranks universities that are doing the most to advance science, develop new technologies and power new industries.
At the top of the list is Stanford University which topped the list due to its stream of patents and research are frequently cited by other academics around the world.
The latest research from Stanford includes developments in artificial intelligence, including the next generation of camera systems to guide self-driving cars and simulators that can predict potential drug interactions.
A few British and Chinese based schools have ascended to the list including the University of Cambridge, University of Oxford, University College London, Shanghai Jiao Tong University, and ZhAJiang University.
Overall, the United States continues to dominate the list, with 46 universities in the top 100; Germany and Japan are tied for the second best country on the list, with nine universities each.
South Korea has eight universities on the list; China, France and the United Kingdom each have 5; Switzerland has 3; Belgium, Canada, Israel and the Netherlands have 2, and Denmark and Singapore each have 1.
On a regional basis, North America has 48 universities in the top 100, Europe has 27, Asia has 23, and the Middle East has 2. There are no universities in the top 100 located in Africa, South America or Oceania.
American universities dominated the list this year. Stanford University came first, The Massachusetts Institute of Technology placed second on the list, and Harvard University comes in third, making 2018 the fourth consecutive year that those universities have held those exact spots.
For more on information on the Reuters Top 100, including a detailed methodology and profiles of the universities, visit the Reuters website.