The strategy, which will see almost a third of its 166 sites go, places thousands of jobs at risk.
The British retailer said 1,200 people were employed at the first 22 stores through it hoped to redeploy some staff.
Here is a list of 22 stores that are set to close first – see if your local Debenhams will be shutting its doors.
:: Birmingham Fort
:: Great Yarmouth
:: Welwyn Garden City